1. Type 2 diabetes-related sEVs appear to modulate the leakiness of the blood brain barrier, suggesting involvement in diabetes-related cognitive impairment.
Gustafon, D. et al. Circulating small extracellular vesicles mediate vascular hyperpermeability in diabetes. Diabetologia (2024). https://doi.org/10.1007/s00125-024-06120-9
2. Hypoxic kidney cells increase secretion of sEVs containing RNA associated with ferroptotic cell death.
Wang, X. et al. Human proximal tubular epithelial cell-derived small extracellular vesicles mediate synchronised tubular ferroptosis in hypoxic kidney injury. Redox Biology, 70, 103042 (2024). https://doi.org/10.1016/j.redox.2024.103042
3. Development of the exosmart drug delivery system by engineering an EV to target pancreatic (PADC) tumours.
Creeden, J. F. et al. Smart exosomes enhance PDAC targeted therapy. Journal of Controlled Release, 368, 413-429 (2024). https://doi.org/10.1016/j.jconrel.2024.02.037
4. Platelet-derived EVs hold therapeutic potential following a heart attack, mediated through their cardioprotective miRNAs and trophic factors.
Livkisa, D. et al. Extracellular vesicles purified from serum-converted human platelet lysates offer strong protection after cardiac ischaemia/reperfusion injury. Biomaterials, 306, 122502 (2024). https://doi.org/10.1016/j.biomaterials.2024.122502
5. Dental stem cell EVs may mediate anti-inflammatory effects in response to neuroinflammation.
Gratpain, V. et al. Influence of a pro-inflammatory stimulus on the miRNA and lipid content of human dental stem cell-derived extracellular vesicles and their impact on microglial activation. Heliyon, 10(5), e27025 (2024). https://doi.org/10.1016/j.heliyon.2024.e27025
6. Small EVs released by acute myeloid leukaemia cells may be disrupting the normal differentiation and proliferation of bone marrow stem cells.
Chetty, V. C. et al. Y-box binding protein 1 in small extracellular vesicles reduces mesenchymal stem cell differentiation to osteoblasts—implications for acute myeloid leukaemia. Journal of Extracellular Vesicles, 13, e12417 (2024). https://doi.org/10.1002/jev2.12417
7. Therapeutic potential of sEV miRNA derived from a subpopulation of umbilical cord stem cells in treating premature infants with white matter injuries.
Tscherigg, V. et al. All but small: miRNAs from Wharton’s jelly-mesenchymal stromal cell small extracellular vesicles rescue premature white matter injury after intranasal administration. Cells, 13(6), 543 (2024). https://doi.org/10.3390/cells13060543
8. EVs from early stage osteogenic MSCs could hold bone therapy applications.
Al-Sharabi, N. et al. Osteogenic human MSC-derived extracellular vesicles regulate MSC activity and osteogenic differentiation and promote bone regeneration in a rat calvarial defect model. Stem Cell Research & Therapy, 15, 33 (2024). https://doi.org/10.1186/s13287-024-03639-x
9. High quality EVs isolated from brain tissue enable investigations into links with depression.
Ibrahim, P. et al. Profiling small RNA from brain extracellular vesicles in individuals with depression. International Journal of Neuropsychopharmacology, 27(3), pyae013 (2024). https://doi.org/10.1093/ijnp/pyae013
10. Profiling EVs found in an ovarian cancer microenvironment improves tumour understanding and has potential diagnostic benefits.
Vyhlídalová Kotrbová, A. et al. Proteomic analysis of ascitic extracellular vesicles describes tumour microenvironment and predicts patient survival in ovarian cancer. Journal of Extracellular Vesicles, 13, e12420 (2024). https://doi.org/10.1002/jev2.12420
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