Abstract Circling exosomal PD-L1 can be expected as a predictor for the clinical responds of anti-PD-1/PD-L1 therapy. Here, we present a simple method integrating capture and analysis of exosomal PD-L1 …
Modification of casein aggregate microstructures under frozen conditions: a study using tunable resistive pulse sensing
Abstract Freezing and aging under frozen conditions could be a potential technique for modifying characteristics of aggregated sodium caseinate particles. In this research, 1% sodium caseinate suspensions with different NaCl …
The Impact of Nylon-3 Copolymer Composition on the Efficiency of siRNA Delivery to Glioblastoma Cells
Abstract Glioblastoma multiforme is a devastating disease that has attracted enormous attention due to poor prognosis and high recurrence. Small interfering RNA (siRNA) in principle offers a promising therapeutic approach …
PEI/NONOates-doped PLGA nanoparticles for eradicating methicillin-resistant Staphylococcus aureus biofilm in diabetic wounds via binding to the biofilm matrix
Abstract Wounds infected with methicillin-resistant Staphylococcus aureus (MRSA) biofilm represent a high risk in patients with diabetes. Nitric oxide (NO) has shown promise in dispersing biofilm and wound healing. For …
Intracranial Non-thermal Ablation Mediated by Transcranial Focused Ultrasound and Phase-Shift Nanoemulsions
Abstract High intensity focused ultrasound (HIFU) mechanical ablation is an emerging technique for non-invasive transcranial surgery. Lesions are created by driving inertial cavitation in tissue, which requires significantly less peak …
Surface-engineered Design of Efficient Luminescent Europium(III) Complex-based Hydroxyapatite Nanocrystals for Rapid HeLa Cancer Cell Imaging
Abstract We synthesized hydroxyapatite nanocrystals under the existence of tris(2,2,6,6-tetramethyl-3,5-heptanedionato)europium(III) (EuTH) complex to form inorganic/organic hybrid nanocrystal (EHA). Then, the folic acid derivative (folate N-hydroxysuccinimidyl ester (FA-NHS)) as the targeting …
Characterization of Nanomaterials: Tools and Challenges
Abstract As the use and potential use of nanomaterials (NMs) in food and food-related products increases, the need for well-defined and established methods for characterization of NM properties is essential …
Gold Nanoparticles with Ligand/Zwitterion Hybrid Layer for Individual Counting of Influenza A H1N1 Subtype Using Resistive Pulse Sensing
Resistive pulse sensing (RPS) is an analytical technique for detecting particles with nano- to micrometer diameters, such as proteins, viruses, and bacteria. RPS is a promising tool for diagnosis as …
Transmembrane NADH Oxidation with Tetracyanoquinodimethane
The design of efficient schemes for nicotinamide adenine dinucleotide (NAD) regeneration is essential for the development of enzymatic biotechnological processes in order to sustain continuous production. In line with our …
Measuring the size and density of nanoparticles by centrifugal sedimentation and flotation
The successful translation of nanoparticle-based systems into commercial products depends upon the ability to reliably measure important physical and chemical properties of these particles. The density of nanoparticles is one …
Measuring the size and density of nanoparticles by centrifugal sedimentation and flotation
The successful translation of nanoparticle-based systems into commercial products depends upon the ability to reliably measure important physical and chemical properties of these particles. The density of nanoparticles is one …
Facile Functionalization of Gold Nanoparticles with PLGA Polymer Brushes and Efficient Encapsulation into PLGA Nanoparticles: Toward Spatially Precise Bioimaging of Polymeric Nanoparticles
Abstract Nanocarriers prepared from poly(lactide‐co‐glycolide) (PLGA) have broad biomedical applications. Understanding their cellular uptake and distribution requires appropriate visualization in complex biological compartments with high spatial resolution, which cannot be …
Nano-/Microparticle Tracers for Evaluating Structures in Fractured Porous Media
Nano- and microparticle tracers are expected to be used for evaluating structures in geological developments, however their transport behavior is not well characterized. This study investigated nanoparticle transport in a …
On-a-chip tryptic digestion of transthyretin: a step toward an integrated microfluidic system for the follow-up of familial transthyretin amyloidosis
A microfluidic microreactor for trypsin mediated transthyretin (TTR) digestion has been developed as a step towards the elaboration of a fully integrated microdevice for the detection of a rare and …
Multiplex Fluorescent Immunoassay Device Based on Magnetic Nanoparticles
Immunofluorescent analyzer based compact disc for simultaneous detection of 3 antibiotics in the same milk sample is consisting of two parts: CD-based immunofluorescence kit and optoelectronic fluorometer. Kit consists of …
Single molecule characterisation of metal nanoparticles using nanopore-based stochastic detection methods
Single-molecule techniques are revolutionising analytical chemistry methods by observing one molecule at a time, the specific dynamics of populations can be revealed, and the averaging of signals from many molecules, …
Synthesis and characterization of noble metal–titania core–shell nanostructures with tunable shell thickness
Core–shell nanostructures have found applications in many fields, including surface enhanced spectroscopy, catalysis and solar cells. Titania-coated noble metal nanoparticles, which combine the surface plasmon resonance properties of the core …
Antigen-loaded pH-sensitive hydrogel microparticles are taken up by dendritic cells with no requirement for targeting antibodies
Particle-based delivery of encapsulated antigens has great potential for improving vaccine constructs. In this study, we show that antigen-loaded, pH-sensitive hydrogel microparticles are taken up and presented by bone marrow-derived …
Sepia ink as a surrogate for colloid transport tests in porous media
We examined the suitability of the ink of Sepia officinalis as a surrogate for transport studies of microorganisms and microparticles in porous media. Sepia ink is an organic pigment consisted …
Multimodal Dispersion of Nanoparticles: A Comprehensive Evaluation of Size Distribution with 9 Size Measurement Methods
Purpose Evaluation of particle size distribution (PSD) of multimodal dispersion of nanoparticles is a difficult task due to inherent limitations of size measurement methods. The present work reports the evaluation …
