Transform your research with precision and accuracy

Measure Nanoparticles with Unparalleled Precision.



Measure individual particle size, concentration, and charge, with unparallelled precision and accuracy.  Tunable Resistive Pulse Sensing (TRPS) measures nanoparticles suspended in electrolytes on a particle-by-particle basis as they pass through a nanopore. This is a huge step forward as the more commonly used light scattering techniques only provide bulk estimates with low accuracy and very low precision. Used in over 45 countries, and included in over 400 publications, TRPS instruments are a key requirement for analysing nanoparticles scientifically and correctly.

Unparalleled accuracy

Measure individual nanoparticles, with sub-nm precision.


Simultaneous size & concentration measurement

Obtain accurate particle concentration in each size band. Read more


Single -particle zeta potential measurement

Measure the zeta potential of each individual particle. Read more


Measure individual particles, with sub-nm precision.



The precision, resolution, and accuracy of size measurement in TRPS is unmatched by any other nanoparticle analysis technique. The transient current pulse caused by a particle traversing the pore is directly proportional to particle volume, enabling a highly precise and repeatable measurement of size to be achieved; in ideal conditions TRPS offers sub nm resolution of diameter. Every particle measured is compared to a set of NIST traceable calibration particles of known size, which ensures accuracy and repeatability. This calibration step enables the real size distribution of a particle set to be generated to a very high precision and accuracy. The measurement of particle concentration is also the best available, with data accuracy on a linear scale. By way of comparison, DLS is unable to measure concentration at all, and NTA is only accurate on a log scale and is too coarse for most scientific purposes.









Measure individual particles, with sub-nm precision.


The precision, resolution, and accuracy of size measurement in TRPS is unmatched by any other nanoparticle analysis technique. The transient current pulse caused by a particle traversing the pore is directly proportional to particle volume, enabling a highly precise and repeatable measurement of size to be achieved; in ideal conditions TRPS offers sub nm resolution of diameter. Every particle measured is compared to a set of NIST traceable calibration particles of known size, which ensures accuracy and repeatability. This calibration step enables the real size distribution of a particle set to be generated to a very high precision and accuracy. The measurement of particle concentration is also the best available, with data accuracy on a linear scale. By way of comparison, DLS is unable to measure concentration at all, and NTA is only accurate on a log scale and is too coarse for most scientific purposes.





Simultaneous size and concentration measurement.



TRPS provides a calibrated measurement of the true size and concentration distribution of nanoparticles. It adds an additional layer of essential information by providing the concentration of particles in each size band. A 2-D histogram of concentration vs size is the correct way to describe nanoparticles. A vague wavy line on a log scale is not.
In fields such as nanomedicine, particle number and size both need to be known to design, predict, and monitor the particle and drug interactions. Size and concentration are both essential components of physico-chemical equivalence, as is surface charge. Aggregation assessments also require both the size and number of particles to be known before and after the change. In the EV field, particles are typically very heterogeneous. A standardised approach to measuring them is required, which TRPS does inherently. Small changes in EV properties may indicate important biomedical or research information. It is a requirement, therefore, that the measurement data is accurate and detailed enough for the user to be confident that those differences are real and correctly quantified.

Read more


Simultaneous size and concentration measurement.


TRPS provides a calibrated measurement of the true size and concentration distribution of nanoparticles. It adds an additional layer of essential information by providing the concentration of particles in each size band. A 2-D histogram of concentration vs size is the correct way to describe nanoparticles. A vague wavy line on a log scale is not.
In fields such as nanomedicine, particle number and size both need to be known to design, predict, and monitor the particle and drug interactions. Size and concentration are both essential components of physico-chemical equivalence, as is surface charge. Aggregation assessments also require both the size and number of particles to be known before and after the change. In the EV field, particles are typically very heterogeneous. A standardised approach to measuring them is required, which TRPS does inherently. Small changes in EV properties may indicate important biomedical or research information. It is a requirement, therefore, that the measurement data is accurate and detailed enough for the user to be confident that those differences are real and correctly quantified.

Read more


Single-particle zeta potential measurement.



The unique capability of TRPS to simultaneously measure particle size and zeta potential (which is a measure of surface charge) reproducibly on a particle-by-particle basis with high precision and accuracy presents a new and powerful approach for the life sciences. Applications include: investigating and understanding nano-bio interactions, establishing physico-chemical equivalence, and the discrimination of sub-populations within a sample. Through the use of charged probes like aptamers biological equivalence can also be confirmed or not.

Read more


Zeta Potential



Zeta Potential


Single-particle zeta potential measurement.


The unique capability of TRPS to simultaneously measure particle size and zeta potential (which is a measure of surface charge) reproducibly on a particle-by-particle basis with high precision and accuracy presents a new and powerful approach for the life sciences. Applications include: investigating and understanding nano-bio interactions, establishing physico-chemical equivalence, and the discrimination of sub-populations within a sample. Through the use of charged probes like aptamers biological equivalence can also be confirmed or not.

Read more

  • Exosomes

    Fast, easy & pure isolation. Accurate & dependable measurement. Read more

  • Nanomedicine

    A comprehensive measurement suite for nanosized drug products. Read more

  • Vaccine and Virus Formulation

    Truely quantitative measurement of total viral bacterial titer. Read more

  • General particles and bubbles

    Highly accurate & quantitative measurement of individual particles & bubbles. Read more

  • Diagnostics

    Validate your development data with TRPS measurements. Read more




Whatever particle you’re measuring, TRPS has you covered.



TRPS is used in a wide range of applications. Select your field to read relevant publications & case studies.


Whatever particle you’re measuring, TRPS has you covered.


TRPS is used in a wide range of applications. Select your field below to read relevant publications & case studies.


  • Exosomes

    Fast & accurate EV isolation and measurement. Read more

  • Nanomedicine

    A comprehensive measurement suite for nanosized drug products. Read more

  • Vaccine and Virus Formulation

    Truely quantitative measurement of total viral bacterial titer. Read more

  • Microbubbles

    Highly accurate & quantitive measurement of individual bubbles. Read more

  • Diagnostics

    Powerful biosensing platform for invitro and invivo applications. Read more



Andrew Devitt
Aston University


“TRPS has proved to be an invaluable tool for us in our studies of the cell biology of extracellular vesicles and the analyses of liposomal adjuvants.  It provides us particle-by-particle analyses with true measures of size and concentration.  Having worked now with this quality of data, I’m always rather surprised that people still resort to composite measures (e.g. DLS) or inferential measures (e.g. NTA).  TRPS now forms part of all our routine measures of particles.”

“TRPS has proved to be an invaluable tool for us in our studies of the cell biology of extracellular vesicles and the analyses of liposomal adjuvants.  It provides us particle-by-particle analyses with true measures of size and concentration.  Having worked now with this quality of data, I’m always rather surprised that people still resort to composite measures (e.g. DLS) or inferential measures (e.g. NTA).  TRPS now forms part of all our routine measures of particles.”


Andrew Devitt
Aston University





Introducing the qNano Gold.



The qNano Gold incorporates TRPS technology into a convenient bench-top device. Simply plug the instrument into a laptop and you can quickly measure the size, concentration and the zeta potential of each individual particle.

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